For each macaque gene, we provided a Gene Page here to illustrate detailed functional annotations in different categories, such as gene information, expression profile, regulation, variation and repeats, phenotypes and disease, function, as well as drug development.

Summary
Entrez ID: 705684 (Human: 8811)
Offical Symbol: GALR2 (Human: GALR2)
Strand: +
Location: chr16:71419030-71421679
Gene Biotype: protein-coding
Full Name: galanin receptor 2
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Alias: N.A.
RefSeq: (NW_001102983.1, XM_001103768.2, XP_001103768.1) (NC_007873.1, XM_001103768.2, XP_001103768.1)
Ensembl: (ENSMMUG00000008882, ENSMMUT00000012422, ENSMMUP00000011651)
UniGene: N.A.
UniProt: F7DT99 (F7DT99_MACMU)
Publications: N.A.
Wiki: Wikipedia, WikiGenes, GeneCard
RefSeq Summary:

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: BC069130.1, AF040630.1 [ECO:0000332] ##RefSeq-Attributes-END## Refer to NM_003857.

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Structure
RefSeq
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RNA(1)
>gi|297273674|ref|XM_001103768.2| PREDICTED: Macaca mulatta galanin receptor 2 (GALR2), mRNA1292nt Get Sequence
[+]
Protein(1)
>gi|109118354|ref|XP_001103768.1| PREDICTED: galanin receptor type 2 [Macaca mulatta]387AA Get Sequence
[+]
Ensembl
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RNA(1)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT000000124221306nt
[+]
RhesusBase2 Gene
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RNA(1)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT00000012422.11306nt
[+]
Expression
RNA-seq
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RPKM
Reference RNA: 
IMMRT10000035060 (chr16:71419016-71421680, 1306bps)
View:
Lab: 
Burge Charles Gilad2010 Gilad2011 JD Kaessmann Norgren Philipp RB Soojin Wang Yi
Sample: 
brain caudate nucleus cerebellum colon fat frontal cerebral cortex frontal pole heart
hippocampus kidney liver lung lymphoblastoid muscle orbital cerebral cortex spleen
testis thymus
RhesusBase IDLabIndividualSampleRPKM?RPKM Level Housekeeping GenesRB Score?More
RBNGS0120008 Burge A testis 0.62 (50.06)
237.29 (99.55) Full [+] 7.23 (80.93) [+]
RBNGS0120002 Burge A heart 0.12 (51.32)
814.11 (99.94) Full [+] 5.48 (20.62) [+]
RBNGS0120015 Burge B muscle 0.10 (52.3)
869.75 (99.94) Full [+] 6.18 (45.88) [+]
RBNGS0120006 Burge A muscle 0.09 (59.9)
10528.36 (99.98) Full [+] 6.54 (54.12) [+]
RBNGS0120009 Burge B brain 0.09 (44.12)
593.73 (99.98) Full [+] 7.66 (88.14) [+]
RBNGS0120017 Burge B testis 0.08 (35.1)
105.21 (99.15) Full [+] 7.69 (89.18) [+]
RBNGS0120011 Burge B heart 0.04 (47.78)
7151.00 (99.98) Full [+] 7.65 (86.6) [+]
RBNGS0120026 Burge C testis 0.04 (28.32)
123.59 (99.40) Full [+] 7.16 (78.87) [+]
RBNGS0120024 Burge C muscle 0.03 (42.7)
3166.11 (99.96) Full [+] 6.78 (64.43) [+]
RBNGS0120019 Burge C colon 0.03 (39.38)
546.43 (99.88) Full [+] 7.01 (74.74) [+]
RBNGS0120021 Burge C kidney 0.03 (37.71)
208.26 (99.76) Full [+] 6.88 (70.1) [+]
RBNGS0120016 Burge B spleen 0.01 (35.92)
243.82 (99.72) Full [+] 7.32 (82.99) [+]
RBNGS0120012 Burge B kidney 0.01 (35.96)
694.13 (99.93) Full [+] 7.59 (85.05) [+]
RBNGS0120010 Burge B colon 0.01 (35.57)
433.31 (99.85) Full [+] 7.65 (86.6) [+]
RBNGS0120014 Burge B lung 0.01 (34.88)
169.19 (99.56) Full [+] 7.58 (84.02) [+]
RBNGS0120000 Burge A brain 0.00 (18.0)
552.62 (99.98) Full [+] 6.68 (60.31) [+]
RBNGS0120001 Burge A colon 0.00 (19.5)
426.94 (99.88) Full [+] 6.59 (57.22) [+]
RBNGS0120003 Burge A kidney 0.00 (20.74)
522.74 (99.88) Full [+] 5.97 (40.72) [+]
RBNGS0120004 Burge A liver 0.00 (20.37)
367.17 (99.72) Full [+] 7.07 (75.77) [+]
RBNGS0120005 Burge A lung 0.00 (16.94)
85.86 (99.12) Full [+] 6.92 (71.65) [+]
RBNGS0120007 Burge A spleen 0.00 (17.51)
152.34 (99.53) Full [+] 6.81 (65.98) [+]
RBNGS0120013 Burge B liver 0.00 (19.58)
370.40 (99.71) Full [+] 7.78 (90.21) [+]
RBNGS0120018 Burge C brain 0.00 (18.77)
601.19 (99.99) Full [+] 6.36 (52.06) [+]
RBNGS0120020 Burge C heart 0.00 (21.69)
559.13 (99.91) Full [+] 5.48 (20.62) [+]
RBNGS0120022 Burge C liver 0.00 (20.91)
252.91 (99.55) Full [+] 7.1 (76.8) [+]
RBNGS0120023 Burge C lung 0.00 (18.13)
132.98 (99.35) Full [+] 7.14 (77.84) [+]
RBNGS0120025 Burge C spleen 0.00 (18.81)
134.12 (99.41) Full [+] 6.95 (73.71) [+]
RBNGS0120032 Charles 303-97 lymphoblastoid 0.28 (56.31)
3680.10 (100.00) Full [+] 5.92 (38.66) [+]
RBNGS0120031 Charles 265-95 lymphoblastoid 0.15 (52.89)
4220.63 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120030 Charles 256-95 lymphoblastoid 0.15 (52.97)
3288.60 (99.98) Full [+] 5.81 (32.47) [+]
RBNGS0120027 Charles 150-99 lymphoblastoid 0.09 (47.47)
3590.65 (99.99) Full [+] 5.9 (37.63) [+]
RBNGS0120028 Charles 153-99 lymphoblastoid 0.00 (25.49)
4927.60 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120029 Charles 173-02 lymphoblastoid 0.00 (23.51)
3034.59 (99.99) Full [+] 5.81 (32.47) [+]
RBNGS0120033 Gilad2010 female1 liver 0.00 (20.8)
246.59 (99.52) Full [+] 5.67 (24.23) [+]
RBNGS0120034 Gilad2010 female2 liver 0.00 (21.74)
265.16 (99.54) Full [+] 5.58 (22.16) [+]
RBNGS0120035 Gilad2010 female3 liver 0.00 (20.01)
509.01 (99.75) Full [+] 5.71 (26.8) [+]
RBNGS0120036 Gilad2010 male1 liver 0.00 (21.11)
284.57 (99.59) Full [+] 5.74 (29.38) [+]
RBNGS0120037 Gilad2010 male2 liver 0.00 (21.16)
342.77 (99.68) Full [+] 5.13 (15.98) [+]
RBNGS0120038 Gilad2010 male3 liver 0.00 (21.33)
295.78 (99.68) Full [+] 5.77 (30.41) [+]
RBNGS0120039 Gilad2011 RNA R1 lymphoblastoid 0.00 (24.3)
2783.10 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120040 Gilad2011 RNA R2 lymphoblastoid 0.00 (24.26)
2909.34 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120041 Gilad2011 RNA R3 lymphoblastoid 0.00 (24.07)
2868.12 (99.99) Full [+] 5.98 (43.3) [+]
RBNGS0120042 JD mixtured frontal cerebral cortex 0.07 (37.67)
997.88 (99.99) Full [+] 6.08 (44.85) [+]
RBNGS0120043 Kaessmann female brain 0.24 (44.39)
1041.37 (99.99) Full [+] 5.88 (36.6) [+]
RBNGS0120048 Kaessmann male1 brain 0.18 (44.2)
1215.60 (99.99) Full [+] 7.17 (79.9) [+]
RBNGS0120054 Kaessmann male2 brain 0.14 (41.59)
798.21 (99.99) Full [+] 5.23 (17.01) [+]
RBNGS0120049 Kaessmann male1 cerebellum 0.07 (40.21)
647.87 (99.97) Full [+] 5.71 (26.8) [+]
RBNGS0120052 Kaessmann male1 liver 0.04 (44.81)
1067.66 (99.83) Full [+] 6.77 (63.4) [+]
RBNGS0120044 Kaessmann female cerebellum 0.00 (19.08)
544.80 (99.97) Full [+] 5.61 (23.2) [+]
RBNGS0120045 Kaessmann female heart 0.00 (20.98)
764.28 (99.91) Full [+] 5.25 (18.04) [+]
RBNGS0120046 Kaessmann female kidney 0.00 (19.88)
1081.82 (99.97) Full [+] 5.72 (28.35) [+]
RBNGS0120047 Kaessmann female liver 0.00 (21.42)
600.89 (99.75) Full [+] 6.19 (46.91) [+]
RBNGS0120050 Kaessmann male1 heart 0.00 (19.72)
599.06 (99.87) Full [+] 5.32 (19.07) [+]
RBNGS0120051 Kaessmann male1 kidney 0.00 (20.11)
711.25 (99.96) Full [+] 4.07 (13.92) [+]
RBNGS0120053 Kaessmann male1 testis 0.00 (16.3)
79.24 (97.96) Full [+] 5.81 (32.47) [+]
RBNGS0120055 Kaessmann male2 testis 0.00 (16.37)
73.01 (97.21) Full [+] 7.29 (81.96) [+]
RBNGS0120057 Norgren 001T NHP orbital cerebral cortex 0.75 (56.66)
465.11 (99.89) Full [+] 6.72 (61.34) [+]
RBNGS0120058 Norgren 001T NHP testis 0.59 (54.69)
361.93 (99.82) Full [+] 6.63 (58.76) [+]
RBNGS0120062 Norgren BF21178 frontal cerebral cortex 0.36 (52.38)
975.49 (99.99) Full [+] 6.81 (65.98) [+]
RBNGS0120066 Norgren BF23773 frontal cerebral cortex 0.17 (48.77)
780.30 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120061 Norgren BF20336 frontal cerebral cortex 0.13 (47.82)
893.81 (99.99) Full [+] 6.85 (68.56) [+]
RBNGS0120063 Norgren BF22215 frontal cerebral cortex 0.12 (48.22)
888.73 (99.97) Full [+] 6.63 (58.76) [+]
RBNGS0120059 Norgren 001T NHP thymus 0.08 (50.14)
898.83 (99.94) Full [+] 6.88 (70.1) [+]
RBNGS0120060 Norgren 002T NHP caudate nucleus 0.07 (47.99)
913.62 (99.97) Full [+] 6.93 (72.68) [+]
RBNGS0120056 Norgren 001T NHP caudate nucleus 0.05 (46.37)
634.09 (99.93) Full [+] 6.83 (67.53) [+]
RBNGS0120064 Norgren BF23762 frontal cerebral cortex 0.00 (21.27)
703.56 (99.97) Full [+] 6.35 (51.03) [+]
RBNGS0120065 Norgren BF23764 frontal cerebral cortex 0.00 (21.71)
639.64 (99.96) Full [+] 6.32 (50.0) [+]
RBNGS0120067 Philipp individual brain 0.00 (25.77)
126.37 (99.90) Full [+] 2.33 (9.79) [+]
RBNGS0120077 RB 0605151 testis 0.56 (47.4)
267.33 (99.88) Full [+] 8.59 (94.85) [+]
RBNGS0120075 RB 0605151 muscle 0.24 (55.03)
4525.95 (99.98) Full [+] 8.76 (99.48) [+]
RBNGS0120070 RB 0605151 fat 0.11 (47.42)
208.39 (99.62) Full [+] 8.59 (94.85) [+]
RBNGS0120072 RB 0605151 kidney 0.11 (46.52)
574.03 (99.91) Full [+] 7.86 (91.75) [+]
RBNGS0120068 RB 0605151 brain 0.08 (43.06)
910.13 (99.99) Full [+] 8.23 (93.3) [+]
RBNGS0120069 RB 0605151 cerebellum 0.05 (43.21)
705.06 (99.99) Full [+] 7.86 (91.75) [+]
RBNGS0120071 RB 0605151 heart 0.05 (48.25)
654.26 (99.90) Full [+] 6.75 (62.37) [+]
RBNGS0120074 RB 0605151 lung 0.04 (38.69)
256.42 (99.77) Full [+] 8.67 (97.42) [+]
RBNGS0120073 RB 0605151 liver 0.02 (45.02)
412.47 (99.69) Full [+] 8.75 (98.45) [+]
RBNGS0120076 RB 0605151 spleen 0.00 (19.37)
255.19 (99.72) Full [+] 8.62 (96.39) [+]
RBNGS0120088 Soojin Y04-21 frontal pole 0.37 (78.39)
0.00 (31.03) Full [+] 2.5 (11.86) [+]
RBNGS0120078 Soojin Y04-03 caudate nucleus 0.00 (49.34)
0.00 (49.34) Full [+] 1.77 (2.58) [+]
RBNGS0120079 Soojin Y04-03 frontal pole 0.00 (31.36)
0.00 (31.36) Full [+] 2.45 (10.82) [+]
RBNGS0120080 Soojin Y04-03 hippocampus 0.00 (49.36)
0.00 (49.36) Full [+] 1.88 (5.67) [+]
RBNGS0120081 Soojin Y04-05 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.68 (1.55) [+]
RBNGS0120082 Soojin Y04-05 frontal pole 0.00 (45.92)
0.00 (45.92) Full [+] 3.36 (12.89) [+]
RBNGS0120083 Soojin Y04-05 hippocampus 0.00 (49.5)
0.00 (49.50) Full [+] 1.9 (6.7) [+]
RBNGS0120084 Soojin Y04-20 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.54 (0.52) [+]
RBNGS0120085 Soojin Y04-20 frontal pole 0.00 (49.78)
0.00 (49.78) Full [+] 2.1 (8.76) [+]
RBNGS0120086 Soojin Y04-20 hippocampus 0.00 (49.74)
0.00 (49.74) Full [+] 1.94 (7.73) [+]
RBNGS0120087 Soojin Y04-21 caudate nucleus 0.00 (49.4)
0.00 (49.40) Full [+] 1.81 (3.61) [+]
RBNGS0120089 Soojin Y04-21 hippocampus 0.00 (49.46)
0.00 (49.46) Full [+] 1.84 (4.64) [+]
RBNGS0120095 Wang individual testis 0.15 (39.08)
118.24 (98.89) Full [+] 6.42 (53.09) [+]
RBNGS0120091 Wang individual heart 0.07 (46.83)
912.82 (99.92) Full [+] 4.78 (14.95) [+]
RBNGS0120090 Wang individual brain 0.00 (20.19)
917.80 (99.99) Full [+] 6.28 (48.97) [+]
RBNGS0120092 Wang individual kidney 0.00 (20.01)
1393.19 (99.97) Full [+] 6.2 (47.94) [+]
RBNGS0120093 Wang individual liver 0.00 (22.07)
338.16 (99.64) Full [+] 5.98 (43.3) [+]
RBNGS0120094 Wang individual muscle 0.00 (22.07)
5119.89 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120096 Yi individual cerebellum 0.17 (42.62)
520.64 (99.96) Full [+] 5.7 (25.26) [+]
RPKM Comparison
Human 
Macaque 
Mouse 
0.06
 
0.08
 
0.16
 
0.33
 
0.07
 
0.55
 
0.02
 
0.04
 
0.11
 
0.02
 
0.02
 
0.38
 
0.25
 
0.26
 
0.13
 
brain cerebellum heart kidney testis
Percentile Rank Comparison
Human 
Macaque 
Mouse 
23.77
 
33.34
 
26.66
 
38.89
 
36.28
 
42.10
 
19.57
 
36.65
 
37.94
 
19.18
 
28.70
 
39.51
 
24.91
 
35.92
 
28.69
 
brain cerebellum heart kidney testis
Relative RPKM Comparison
Human 
Macaque 
Mouse 
0.000
 
0.000
 
N.A
 
0.000
 
0.000
 
N.A
 
0.000
 
0.000
 
N.A
 
0.000
 
0.000
 
N.A
 
0.000
 
0.001
 
N.A
 
brain cerebellum heart kidney testis