For each macaque gene, we provided a Gene Page here to illustrate detailed functional annotations in different categories, such as gene information, expression profile, regulation, variation and repeats, phenotypes and disease, function, as well as drug development.

Summary
Entrez ID: 705568 (Human: 6730)
Offical Symbol: SRP68 (Human: SRP68)
Strand: -
Location: chr16:71368680-71412431
Gene Biotype: protein-coding
Full Name: signal recognition particle 68kDa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Alias: N.A.
RefSeq: (NW_001102983.1, XM_001103427.2, XP_001103427.2) (NW_001102983.1, XM_001103509.2, XP_001103509.1) (NW_001102983.1, XM_001103595.2, XP_001103595.2) (NW_001102983.1, XM_001103682.2, XP_001103682.2) (NW_001102983.1, XM_002800608.1, XP_002800654.1) (NC_007873.1, XM_001103427.2, XP_001103427.2) (NC_007873.1, XM_001103509.2, XP_001103509.1) (NC_007873.1, XM_001103595.2, XP_001103595.2) (NC_007873.1, XM_001103682.2, XP_001103682.2) (NC_007873.1, XM_002800608.1, XP_002800654.1)
Ensembl: (ENSMMUG00000001795, ENSMMUT00000002524, ENSMMUP00000002387) (ENSMMUG00000001795, ENSMMUT00000002525, ENSMMUP00000002388)
UniGene: Mmu.12090
UniProt: F7GGQ4 (F7GGQ4_MACMU)
Publications: N.A.
Wiki: Wikipedia, WikiGenes, GeneCard
RefSeq Summary:

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]. Refer to NM_001260502.

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Structure
RefSeq
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RNA(5)
>gi|297273665|ref|XM_001103682.2| PREDICTED: Macaca mulatta signal recognition particle 68kDa, transcript variant 8 (SRP68), mRNA2970nt Get Sequence
[+]
>gi|297273671|ref|XM_001103509.2| PREDICTED: Macaca mulatta signal recognition particle 68kDa, transcript variant 6 (SRP68), mRNA2737nt Get Sequence
[+]
>gi|297273667|ref|XM_001103595.2| PREDICTED: Macaca mulatta signal recognition particle 68kDa, transcript variant 7 (SRP68), mRNA2731nt Get Sequence
[+]
>gi|297273669|ref|XM_001103427.2| PREDICTED: Macaca mulatta signal recognition particle 68kDa, transcript variant 5 (SRP68), mRNA2691nt Get Sequence
[+]
>gi|297273672|ref|XM_002800608.1| PREDICTED: Macaca mulatta signal recognition particle 68kDa (SRP68), mRNA2691nt Get Sequence
[+]
Protein(5)
>gi|297273666|ref|XP_001103682.2| PREDICTED: signal recognition particle 68 kDa protein isoform 8 [Macaca mulatta]679AA Get Sequence
[+]
>gi|109118338|ref|XP_001103509.1| PREDICTED: signal recognition particle 68 kDa protein isoform 6 [Macaca mulatta]593AA Get Sequence
[+]
>gi|297273668|ref|XP_001103595.2| PREDICTED: signal recognition particle 68 kDa protein isoform 7 [Macaca mulatta]591AA Get Sequence
[+]
>gi|297273670|ref|XP_001103427.2| PREDICTED: signal recognition particle 68 kDa protein isoform 5 [Macaca mulatta]584AA Get Sequence
[+]
>gi|297273673|ref|XP_002800654.1| PREDICTED: signal recognition particle 68 kDa protein [Macaca mulatta]526AA Get Sequence
[+]
Ensembl
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RNA(2)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT000000025252474nt
[+]
>ENSMMUT000000025242365nt
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RhesusBase2 Gene
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RNA(2)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT00000002525.1; Revisions: 3'UTR (chr16:71368698-71369012)2788nt
[+]
>ENSMMUT00000002524.1; Revisions: 3'UTR (chr16:71368698-71369012)2679nt
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Expression
RNA-seq
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RPKM
Reference RNA: 
IMMRT10011035059 (chr16:71368772-71412273, 2719bps)
View:
Lab: 
Burge Charles Gilad2010 Gilad2011 JD Kaessmann Norgren Philipp RB Soojin Wang Yi
Sample: 
brain caudate nucleus cerebellum colon fat frontal cerebral cortex frontal pole heart
hippocampus kidney liver lung lymphoblastoid muscle orbital cerebral cortex spleen
testis thymus
RhesusBase IDLabIndividualSampleRPKM?RPKM Level Housekeeping GenesRB Score?More
RBNGS0120011 Burge B heart 37.48 (97.28)
7151.00 (99.98) Full [+] 7.65 (86.6) [+]
RBNGS0120018 Burge C brain 31.41 (96.48)
601.19 (99.99) Full [+] 6.36 (52.06) [+]
RBNGS0120009 Burge B brain 30.24 (96.23)
593.73 (99.98) Full [+] 7.66 (88.14) [+]
RBNGS0120008 Burge A testis 29.41 (92.57)
237.29 (99.55) Full [+] 7.23 (80.93) [+]
RBNGS0120026 Burge C testis 29.08 (93.97)
123.59 (99.40) Full [+] 7.16 (78.87) [+]
RBNGS0120014 Burge B lung 28.50 (95.7)
169.19 (99.56) Full [+] 7.58 (84.02) [+]
RBNGS0120001 Burge A colon 27.88 (94.84)
426.94 (99.88) Full [+] 6.59 (57.22) [+]
RBNGS0120000 Burge A brain 26.82 (96.06)
552.62 (99.98) Full [+] 6.68 (60.31) [+]
RBNGS0120017 Burge B testis 26.78 (93.73)
105.21 (99.15) Full [+] 7.69 (89.18) [+]
RBNGS0120024 Burge C muscle 26.14 (96.27)
3166.11 (99.96) Full [+] 6.78 (64.43) [+]
RBNGS0120019 Burge C colon 26.09 (93.7)
546.43 (99.88) Full [+] 7.01 (74.74) [+]
RBNGS0120023 Burge C lung 25.22 (94.18)
132.98 (99.35) Full [+] 7.14 (77.84) [+]
RBNGS0120021 Burge C kidney 25.12 (94.85)
208.26 (99.76) Full [+] 6.88 (70.1) [+]
RBNGS0120005 Burge A lung 24.67 (95.04)
85.86 (99.12) Full [+] 6.92 (71.65) [+]
RBNGS0120012 Burge B kidney 24.46 (93.94)
694.13 (99.93) Full [+] 7.59 (85.05) [+]
RBNGS0120020 Burge C heart 24.07 (96.43)
559.13 (99.91) Full [+] 5.48 (20.62) [+]
RBNGS0120016 Burge B spleen 23.14 (94.53)
243.82 (99.72) Full [+] 7.32 (82.99) [+]
RBNGS0120010 Burge B colon 22.40 (93.46)
433.31 (99.85) Full [+] 7.65 (86.6) [+]
RBNGS0120004 Burge A liver 20.80 (94.66)
367.17 (99.72) Full [+] 7.07 (75.77) [+]
RBNGS0120025 Burge C spleen 20.55 (92.76)
134.12 (99.41) Full [+] 6.95 (73.71) [+]
RBNGS0120003 Burge A kidney 20.50 (92.65)
522.74 (99.88) Full [+] 5.97 (40.72) [+]
RBNGS0120007 Burge A spleen 19.76 (93.34)
152.34 (99.53) Full [+] 6.81 (65.98) [+]
RBNGS0120015 Burge B muscle 18.86 (95.46)
869.75 (99.94) Full [+] 6.18 (45.88) [+]
RBNGS0120022 Burge C liver 18.29 (94.35)
252.91 (99.55) Full [+] 7.1 (76.8) [+]
RBNGS0120006 Burge A muscle 16.36 (94.79)
10528.36 (99.98) Full [+] 6.54 (54.12) [+]
RBNGS0120002 Burge A heart 16.29 (94.81)
814.11 (99.94) Full [+] 5.48 (20.62) [+]
RBNGS0120013 Burge B liver 15.28 (93.82)
370.40 (99.71) Full [+] 7.78 (90.21) [+]
RBNGS0120032 Charles 303-97 lymphoblastoid 72.54 (97.57)
3680.10 (100.00) Full [+] 5.92 (38.66) [+]
RBNGS0120029 Charles 173-02 lymphoblastoid 60.84 (97.1)
3034.59 (99.99) Full [+] 5.81 (32.47) [+]
RBNGS0120030 Charles 256-95 lymphoblastoid 54.12 (95.84)
3288.60 (99.98) Full [+] 5.81 (32.47) [+]
RBNGS0120031 Charles 265-95 lymphoblastoid 49.65 (95.85)
4220.63 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120027 Charles 150-99 lymphoblastoid 44.16 (95.58)
3590.65 (99.99) Full [+] 5.9 (37.63) [+]
RBNGS0120028 Charles 153-99 lymphoblastoid 37.66 (94.53)
4927.60 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120038 Gilad2010 male3 liver 36.89 (96.39)
295.78 (99.68) Full [+] 5.77 (30.41) [+]
RBNGS0120035 Gilad2010 female3 liver 25.13 (94.22)
509.01 (99.75) Full [+] 5.71 (26.8) [+]
RBNGS0120033 Gilad2010 female1 liver 21.80 (94.18)
246.59 (99.52) Full [+] 5.67 (24.23) [+]
RBNGS0120036 Gilad2010 male1 liver 16.64 (92.57)
284.57 (99.59) Full [+] 5.74 (29.38) [+]
RBNGS0120034 Gilad2010 female2 liver 14.91 (91.76)
265.16 (99.54) Full [+] 5.58 (22.16) [+]
RBNGS0120037 Gilad2010 male2 liver 13.92 (92.02)
342.77 (99.68) Full [+] 5.13 (15.98) [+]
RBNGS0120041 Gilad2011 RNA R3 lymphoblastoid 64.96 (96.8)
2868.12 (99.99) Full [+] 5.98 (43.3) [+]
RBNGS0120040 Gilad2011 RNA R2 lymphoblastoid 51.09 (95.77)
2909.34 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120039 Gilad2011 RNA R1 lymphoblastoid 45.17 (95.31)
2783.10 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120042 JD mixtured frontal cerebral cortex 35.83 (94.49)
997.88 (99.99) Full [+] 6.08 (44.85) [+]
RBNGS0120055 Kaessmann male2 testis 67.28 (96.8)
73.01 (97.21) Full [+] 7.29 (81.96) [+]
RBNGS0120048 Kaessmann male1 brain 37.87 (95.04)
1215.60 (99.99) Full [+] 7.17 (79.9) [+]
RBNGS0120049 Kaessmann male1 cerebellum 34.94 (95.78)
647.87 (99.97) Full [+] 5.71 (26.8) [+]
RBNGS0120043 Kaessmann female brain 34.30 (95.18)
1041.37 (99.99) Full [+] 5.88 (36.6) [+]
RBNGS0120054 Kaessmann male2 brain 33.62 (95.6)
798.21 (99.99) Full [+] 5.23 (17.01) [+]
RBNGS0120044 Kaessmann female cerebellum 31.96 (96.14)
544.80 (99.97) Full [+] 5.61 (23.2) [+]
RBNGS0120053 Kaessmann male1 testis 31.46 (93.24)
79.24 (97.96) Full [+] 5.81 (32.47) [+]
RBNGS0120050 Kaessmann male1 heart 27.39 (94.4)
599.06 (99.87) Full [+] 5.32 (19.07) [+]
RBNGS0120045 Kaessmann female heart 26.46 (95.69)
764.28 (99.91) Full [+] 5.25 (18.04) [+]
RBNGS0120046 Kaessmann female kidney 24.10 (92.21)
1081.82 (99.97) Full [+] 5.72 (28.35) [+]
RBNGS0120051 Kaessmann male1 kidney 20.84 (93.76)
711.25 (99.96) Full [+] 4.07 (13.92) [+]
RBNGS0120047 Kaessmann female liver 16.42 (92.21)
600.89 (99.75) Full [+] 6.19 (46.91) [+]
RBNGS0120052 Kaessmann male1 liver 15.96 (90.95)
1067.66 (99.83) Full [+] 6.77 (63.4) [+]
RBNGS0120058 Norgren 001T NHP testis 69.63 (97.58)
361.93 (99.82) Full [+] 6.63 (58.76) [+]
RBNGS0120057 Norgren 001T NHP orbital cerebral cortex 61.39 (96.89)
465.11 (99.89) Full [+] 6.72 (61.34) [+]
RBNGS0120064 Norgren BF23762 frontal cerebral cortex 54.34 (96.98)
703.56 (99.97) Full [+] 6.35 (51.03) [+]
RBNGS0120065 Norgren BF23764 frontal cerebral cortex 50.20 (96.72)
639.64 (99.96) Full [+] 6.32 (50.0) [+]
RBNGS0120061 Norgren BF20336 frontal cerebral cortex 49.97 (96.39)
893.81 (99.99) Full [+] 6.85 (68.56) [+]
RBNGS0120066 Norgren BF23773 frontal cerebral cortex 46.93 (96.37)
780.30 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120062 Norgren BF21178 frontal cerebral cortex 43.40 (95.71)
975.49 (99.99) Full [+] 6.81 (65.98) [+]
RBNGS0120060 Norgren 002T NHP caudate nucleus 41.53 (95.32)
913.62 (99.97) Full [+] 6.93 (72.68) [+]
RBNGS0120059 Norgren 001T NHP thymus 38.68 (94.38)
898.83 (99.94) Full [+] 6.88 (70.1) [+]
RBNGS0120056 Norgren 001T NHP caudate nucleus 36.39 (94.75)
634.09 (99.93) Full [+] 6.83 (67.53) [+]
RBNGS0120063 Norgren BF22215 frontal cerebral cortex 31.48 (93.25)
888.73 (99.97) Full [+] 6.63 (58.76) [+]
RBNGS0120067 Philipp individual brain 6.71 (89.6)
126.37 (99.90) Full [+] 2.33 (9.79) [+]
RBNGS0120075 RB 0605151 muscle 30.45 (96.27)
4525.95 (99.98) Full [+] 8.76 (99.48) [+]
RBNGS0120068 RB 0605151 brain 23.02 (94.92)
910.13 (99.99) Full [+] 8.23 (93.3) [+]
RBNGS0120069 RB 0605151 cerebellum 20.73 (94.99)
705.06 (99.99) Full [+] 7.86 (91.75) [+]
RBNGS0120077 RB 0605151 testis 19.76 (92.7)
267.33 (99.88) Full [+] 8.59 (94.85) [+]
RBNGS0120070 RB 0605151 fat 19.31 (93.21)
208.39 (99.62) Full [+] 8.59 (94.85) [+]
RBNGS0120074 RB 0605151 lung 18.15 (92.09)
256.42 (99.77) Full [+] 8.67 (97.42) [+]
RBNGS0120076 RB 0605151 spleen 14.60 (88.98)
255.19 (99.72) Full [+] 8.62 (96.39) [+]
RBNGS0120073 RB 0605151 liver 13.83 (92.01)
412.47 (99.69) Full [+] 8.75 (98.45) [+]
RBNGS0120072 RB 0605151 kidney 13.21 (91.06)
574.03 (99.91) Full [+] 7.86 (91.75) [+]
RBNGS0120071 RB 0605151 heart 8.61 (91.97)
654.26 (99.90) Full [+] 6.75 (62.37) [+]
RBNGS0120079 Soojin Y04-03 frontal pole 0.38 (78.73)
0.00 (31.36) Full [+] 2.45 (10.82) [+]
RBNGS0120088 Soojin Y04-21 frontal pole 0.18 (67.47)
0.00 (31.03) Full [+] 2.5 (11.86) [+]
RBNGS0120078 Soojin Y04-03 caudate nucleus 0.00 (49.34)
0.00 (49.34) Full [+] 1.77 (2.58) [+]
RBNGS0120080 Soojin Y04-03 hippocampus 0.00 (49.36)
0.00 (49.36) Full [+] 1.88 (5.67) [+]
RBNGS0120081 Soojin Y04-05 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.68 (1.55) [+]
RBNGS0120082 Soojin Y04-05 frontal pole 0.00 (45.92)
0.00 (45.92) Full [+] 3.36 (12.89) [+]
RBNGS0120083 Soojin Y04-05 hippocampus 0.00 (49.5)
0.00 (49.50) Full [+] 1.9 (6.7) [+]
RBNGS0120084 Soojin Y04-20 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.54 (0.52) [+]
RBNGS0120085 Soojin Y04-20 frontal pole 0.00 (49.78)
0.00 (49.78) Full [+] 2.1 (8.76) [+]
RBNGS0120086 Soojin Y04-20 hippocampus 0.00 (49.74)
0.00 (49.74) Full [+] 1.94 (7.73) [+]
RBNGS0120087 Soojin Y04-21 caudate nucleus 0.00 (49.4)
0.00 (49.40) Full [+] 1.81 (3.61) [+]
RBNGS0120089 Soojin Y04-21 hippocampus 0.00 (49.46)
0.00 (49.46) Full [+] 1.84 (4.64) [+]
RBNGS0120090 Wang individual brain 35.08 (94.98)
917.80 (99.99) Full [+] 6.28 (48.97) [+]
RBNGS0120094 Wang individual muscle 34.30 (96.14)
5119.89 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120095 Wang individual testis 32.66 (93.11)
118.24 (98.89) Full [+] 6.42 (53.09) [+]
RBNGS0120092 Wang individual kidney 31.32 (93.08)
1393.19 (99.97) Full [+] 6.2 (47.94) [+]
RBNGS0120091 Wang individual heart 17.57 (93.89)
912.82 (99.92) Full [+] 4.78 (14.95) [+]
RBNGS0120093 Wang individual liver 16.49 (93.12)
338.16 (99.64) Full [+] 5.98 (43.3) [+]
RBNGS0120096 Yi individual cerebellum 34.89 (95.54)
520.64 (99.96) Full [+] 5.7 (25.26) [+]
RPKM Comparison
Human 
Macaque 
Mouse 
25.16
 
28.78
 
24.51
 
29.45
 
30.63
 
28.63
 
17.96
 
22.55
 
28.06
 
23.06
 
22.79
 
24.87
 
26.77
 
38.26
 
34.30
 
brain cerebellum heart kidney testis
Percentile Rank Comparison
Human 
Macaque 
Mouse 
91.48
 
94.90
 
90.90
 
92.96
 
95.61
 
92.06
 
91.33
 
94.92
 
92.96
 
90.68
 
93.08
 
90.99
 
89.50
 
94.21
 
91.34
 
brain cerebellum heart kidney testis
Relative RPKM Comparison
Human 
Macaque 
Mouse 
0.038
 
0.042
 
N.A
 
0.036
 
0.052
 
N.A
 
0.022
 
0.026
 
N.A
 
0.033
 
0.042
 
N.A
 
0.051
 
0.309
 
N.A
 
brain cerebellum heart kidney testis