For each macaque gene, we provided a Gene Page here to illustrate detailed functional annotations in different categories, such as gene information, expression profile, regulation, variation and repeats, phenotypes and disease, function, as well as drug development.

Summary
Entrez ID: 703541 (Human: 2683)
Offical Symbol: B4GALT1 (Human: B4GALT1)
Strand: +
Location: chr15:44063224-44119421
Gene Biotype: protein-coding
Full Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Alias: N.A.
RefSeq: (NW_001101662.1, XM_001100938.2, XP_001100938.1) (NW_001101662.1, XM_002800061.1, XP_002800107.1) (NC_007872.1, XM_001100938.2, XP_001100938.1) (NC_007872.1, XM_002800061.1, XP_002800107.1) (-, NM_001258145.1, NP_001245074.1)
Ensembl: (ENSMMUG00000002086, ENSMMUT00000046311, ENSMMUP00000039353) (ENSMMUG00000002086, ENSMMUT00000002948, ENSMMUP00000002785)
UniGene: Mmu.29971
UniProt: F6WPI5 (F6WPI5_MACMU)
Publications: N.A.
Wiki: Wikipedia, WikiGenes, GeneCard
RefSeq Summary:

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: D29805.1, X13223.1 [ECO:0000332] ##RefSeq-Attributes-END## Refer to NM_001497.

Share:
Structure
RefSeq
top help
RNA(1)
>gi|384475856|ref|NM_001258145.1| Macaca mulatta UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4GALT1), mRNA4083nt Get Sequence
[+]
Protein(1)
>gi|384475857|ref|NP_001245074.1| beta-1,4-galactosyltransferase 1 [Macaca mulatta]398AA Get Sequence
[+]
Ensembl
top help
RNA(2)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT000000463111561nt
[+]
>ENSMMUT000000029481403nt
[+]
RhesusBase2 Gene
top help
RNA(2)
Regions revised by RhesusBase (v2.0) are highlighted in red.
>ENSMMUT000000463111561nt
[+]
>ENSMMUT000000029481403nt
[+]
Expression
RNA-seq
top help
RPKM
Reference RNA: 
IMMRT10001032412 (chr15:44063193-44121628, 4219bps)
View:
Lab: 
Burge Charles Gilad2010 Gilad2011 JD Kaessmann Norgren Philipp RB Soojin Wang Yi
Sample: 
brain caudate nucleus cerebellum colon fat frontal cerebral cortex frontal pole heart
hippocampus kidney liver lung lymphoblastoid muscle orbital cerebral cortex spleen
testis thymus
RhesusBase IDLabIndividualSampleRPKM?RPKM Level Housekeeping GenesRB Score?More
RBNGS0120016 Burge B spleen 36.71 (96.99)
243.82 (99.72) Full [+] 7.32 (82.99) [+]
RBNGS0120025 Burge C spleen 31.81 (95.94)
134.12 (99.41) Full [+] 6.95 (73.71) [+]
RBNGS0120007 Burge A spleen 26.75 (95.48)
152.34 (99.53) Full [+] 6.81 (65.98) [+]
RBNGS0120001 Burge A colon 26.21 (94.44)
426.94 (99.88) Full [+] 6.59 (57.22) [+]
RBNGS0120004 Burge A liver 25.72 (95.66)
367.17 (99.72) Full [+] 7.07 (75.77) [+]
RBNGS0120019 Burge C colon 25.07 (93.45)
546.43 (99.88) Full [+] 7.01 (74.74) [+]
RBNGS0120012 Burge B kidney 23.28 (93.59)
694.13 (99.93) Full [+] 7.59 (85.05) [+]
RBNGS0120010 Burge B colon 23.08 (93.66)
433.31 (99.85) Full [+] 7.65 (86.6) [+]
RBNGS0120014 Burge B lung 18.88 (92.74)
169.19 (99.56) Full [+] 7.58 (84.02) [+]
RBNGS0120022 Burge C liver 17.24 (94.01)
252.91 (99.55) Full [+] 7.1 (76.8) [+]
RBNGS0120013 Burge B liver 17.23 (94.52)
370.40 (99.71) Full [+] 7.78 (90.21) [+]
RBNGS0120005 Burge A lung 16.95 (91.94)
85.86 (99.12) Full [+] 6.92 (71.65) [+]
RBNGS0120023 Burge C lung 14.78 (89.04)
132.98 (99.35) Full [+] 7.14 (77.84) [+]
RBNGS0120003 Burge A kidney 13.71 (89.46)
522.74 (99.88) Full [+] 5.97 (40.72) [+]
RBNGS0120021 Burge C kidney 11.43 (87.73)
208.26 (99.76) Full [+] 6.88 (70.1) [+]
RBNGS0120008 Burge A testis 9.51 (81.65)
237.29 (99.55) Full [+] 7.23 (80.93) [+]
RBNGS0120026 Burge C testis 7.64 (78.07)
123.59 (99.40) Full [+] 7.16 (78.87) [+]
RBNGS0120017 Burge B testis 6.89 (79.31)
105.21 (99.15) Full [+] 7.69 (89.18) [+]
RBNGS0120015 Burge B muscle 6.11 (87.21)
869.75 (99.94) Full [+] 6.18 (45.88) [+]
RBNGS0120020 Burge C heart 6.09 (87.13)
559.13 (99.91) Full [+] 5.48 (20.62) [+]
RBNGS0120011 Burge B heart 6.08 (87.19)
7151.00 (99.98) Full [+] 7.65 (86.6) [+]
RBNGS0120002 Burge A heart 6.00 (87.26)
814.11 (99.94) Full [+] 5.48 (20.62) [+]
RBNGS0120006 Burge A muscle 5.76 (89.59)
10528.36 (99.98) Full [+] 6.54 (54.12) [+]
RBNGS0120024 Burge C muscle 4.98 (85.4)
3166.11 (99.96) Full [+] 6.78 (64.43) [+]
RBNGS0120009 Burge B brain 1.07 (61.13)
593.73 (99.98) Full [+] 7.66 (88.14) [+]
RBNGS0120018 Burge C brain 0.73 (58.23)
601.19 (99.99) Full [+] 6.36 (52.06) [+]
RBNGS0120000 Burge A brain 0.70 (58.54)
552.62 (99.98) Full [+] 6.68 (60.31) [+]
RBNGS0120032 Charles 303-97 lymphoblastoid 63.30 (97.12)
3680.10 (100.00) Full [+] 5.92 (38.66) [+]
RBNGS0120028 Charles 153-99 lymphoblastoid 50.21 (95.91)
4927.60 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120029 Charles 173-02 lymphoblastoid 46.23 (96.02)
3034.59 (99.99) Full [+] 5.81 (32.47) [+]
RBNGS0120030 Charles 256-95 lymphoblastoid 43.97 (94.91)
3288.60 (99.98) Full [+] 5.81 (32.47) [+]
RBNGS0120027 Charles 150-99 lymphoblastoid 28.98 (93.19)
3590.65 (99.99) Full [+] 5.9 (37.63) [+]
RBNGS0120031 Charles 265-95 lymphoblastoid 26.55 (92.22)
4220.63 (100.00) Full [+] 5.83 (35.05) [+]
RBNGS0120037 Gilad2010 male2 liver 85.71 (98.68)
342.77 (99.68) Full [+] 5.13 (15.98) [+]
RBNGS0120038 Gilad2010 male3 liver 45.47 (97.2)
295.78 (99.68) Full [+] 5.77 (30.41) [+]
RBNGS0120035 Gilad2010 female3 liver 26.22 (94.49)
509.01 (99.75) Full [+] 5.71 (26.8) [+]
RBNGS0120034 Gilad2010 female2 liver 20.29 (93.93)
265.16 (99.54) Full [+] 5.58 (22.16) [+]
RBNGS0120033 Gilad2010 female1 liver 20.20 (93.68)
246.59 (99.52) Full [+] 5.67 (24.23) [+]
RBNGS0120036 Gilad2010 male1 liver 19.08 (93.6)
284.57 (99.59) Full [+] 5.74 (29.38) [+]
RBNGS0120041 Gilad2011 RNA R3 lymphoblastoid 55.47 (96.14)
2868.12 (99.99) Full [+] 5.98 (43.3) [+]
RBNGS0120039 Gilad2011 RNA R1 lymphoblastoid 43.27 (95.09)
2783.10 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120040 Gilad2011 RNA R2 lymphoblastoid 35.77 (93.66)
2909.34 (99.96) Full [+] 5.97 (40.72) [+]
RBNGS0120042 JD mixtured frontal cerebral cortex 1.01 (52.43)
997.88 (99.99) Full [+] 6.08 (44.85) [+]
RBNGS0120046 Kaessmann female kidney 25.54 (92.67)
1081.82 (99.97) Full [+] 5.72 (28.35) [+]
RBNGS0120047 Kaessmann female liver 22.25 (94.04)
600.89 (99.75) Full [+] 6.19 (46.91) [+]
RBNGS0120050 Kaessmann male1 heart 15.46 (89.96)
599.06 (99.87) Full [+] 5.32 (19.07) [+]
RBNGS0120052 Kaessmann male1 liver 12.81 (89.39)
1067.66 (99.83) Full [+] 6.77 (63.4) [+]
RBNGS0120051 Kaessmann male1 kidney 11.36 (88.04)
711.25 (99.96) Full [+] 4.07 (13.92) [+]
RBNGS0120045 Kaessmann female heart 9.12 (87.85)
764.28 (99.91) Full [+] 5.25 (18.04) [+]
RBNGS0120053 Kaessmann male1 testis 7.06 (76.41)
79.24 (97.96) Full [+] 5.81 (32.47) [+]
RBNGS0120055 Kaessmann male2 testis 4.69 (71.74)
73.01 (97.21) Full [+] 7.29 (81.96) [+]
RBNGS0120044 Kaessmann female cerebellum 1.86 (60.66)
544.80 (99.97) Full [+] 5.61 (23.2) [+]
RBNGS0120049 Kaessmann male1 cerebellum 1.76 (59.45)
647.87 (99.97) Full [+] 5.71 (26.8) [+]
RBNGS0120043 Kaessmann female brain 0.97 (53.41)
1041.37 (99.99) Full [+] 5.88 (36.6) [+]
RBNGS0120048 Kaessmann male1 brain 0.95 (54.14)
1215.60 (99.99) Full [+] 7.17 (79.9) [+]
RBNGS0120054 Kaessmann male2 brain 0.81 (52.02)
798.21 (99.99) Full [+] 5.23 (17.01) [+]
RBNGS0120059 Norgren 001T NHP thymus 58.14 (96.79)
898.83 (99.94) Full [+] 6.88 (70.1) [+]
RBNGS0120057 Norgren 001T NHP orbital cerebral cortex 24.16 (89.71)
465.11 (99.89) Full [+] 6.72 (61.34) [+]
RBNGS0120058 Norgren 001T NHP testis 23.81 (89.52)
361.93 (99.82) Full [+] 6.63 (58.76) [+]
RBNGS0120062 Norgren BF21178 frontal cerebral cortex 2.25 (64.06)
975.49 (99.99) Full [+] 6.81 (65.98) [+]
RBNGS0120065 Norgren BF23764 frontal cerebral cortex 2.22 (63.8)
639.64 (99.96) Full [+] 6.32 (50.0) [+]
RBNGS0120064 Norgren BF23762 frontal cerebral cortex 2.12 (63.46)
703.56 (99.97) Full [+] 6.35 (51.03) [+]
RBNGS0120061 Norgren BF20336 frontal cerebral cortex 2.05 (63.69)
893.81 (99.99) Full [+] 6.85 (68.56) [+]
RBNGS0120066 Norgren BF23773 frontal cerebral cortex 1.85 (62.64)
780.30 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120060 Norgren 002T NHP caudate nucleus 1.80 (63.96)
913.62 (99.97) Full [+] 6.93 (72.68) [+]
RBNGS0120063 Norgren BF22215 frontal cerebral cortex 1.57 (61.83)
888.73 (99.97) Full [+] 6.63 (58.76) [+]
RBNGS0120056 Norgren 001T NHP caudate nucleus 1.32 (61.83)
634.09 (99.93) Full [+] 6.83 (67.53) [+]
RBNGS0120067 Philipp individual brain 1.56 (66.68)
126.37 (99.90) Full [+] 2.33 (9.79) [+]
RBNGS0120076 RB 0605151 spleen 35.87 (96.57)
255.19 (99.72) Full [+] 8.62 (96.39) [+]
RBNGS0120070 RB 0605151 fat 32.81 (96.35)
208.39 (99.62) Full [+] 8.59 (94.85) [+]
RBNGS0120074 RB 0605151 lung 20.21 (93.15)
256.42 (99.77) Full [+] 8.67 (97.42) [+]
RBNGS0120077 RB 0605151 testis 12.52 (87.01)
267.33 (99.88) Full [+] 8.59 (94.85) [+]
RBNGS0120073 RB 0605151 liver 11.42 (90.62)
412.47 (99.69) Full [+] 8.75 (98.45) [+]
RBNGS0120072 RB 0605151 kidney 10.94 (89.19)
574.03 (99.91) Full [+] 7.86 (91.75) [+]
RBNGS0120075 RB 0605151 muscle 9.50 (88.86)
4525.95 (99.98) Full [+] 8.76 (99.48) [+]
RBNGS0120071 RB 0605151 heart 6.39 (89.53)
654.26 (99.90) Full [+] 6.75 (62.37) [+]
RBNGS0120068 RB 0605151 brain 2.18 (66.7)
910.13 (99.99) Full [+] 8.23 (93.3) [+]
RBNGS0120069 RB 0605151 cerebellum 1.96 (67.65)
705.06 (99.99) Full [+] 7.86 (91.75) [+]
RBNGS0120088 Soojin Y04-21 frontal pole 0.12 (63.86)
0.00 (31.03) Full [+] 2.5 (11.86) [+]
RBNGS0120078 Soojin Y04-03 caudate nucleus 0.00 (49.34)
0.00 (49.34) Full [+] 1.77 (2.58) [+]
RBNGS0120079 Soojin Y04-03 frontal pole 0.00 (31.36)
0.00 (31.36) Full [+] 2.45 (10.82) [+]
RBNGS0120080 Soojin Y04-03 hippocampus 0.00 (49.36)
0.00 (49.36) Full [+] 1.88 (5.67) [+]
RBNGS0120081 Soojin Y04-05 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.68 (1.55) [+]
RBNGS0120082 Soojin Y04-05 frontal pole 0.00 (45.92)
0.00 (45.92) Full [+] 3.36 (12.89) [+]
RBNGS0120083 Soojin Y04-05 hippocampus 0.00 (49.5)
0.00 (49.50) Full [+] 1.9 (6.7) [+]
RBNGS0120084 Soojin Y04-20 caudate nucleus 0.00 (49.92)
0.00 (49.92) Full [+] 1.54 (0.52) [+]
RBNGS0120085 Soojin Y04-20 frontal pole 0.00 (49.78)
0.00 (49.78) Full [+] 2.1 (8.76) [+]
RBNGS0120086 Soojin Y04-20 hippocampus 0.00 (49.74)
0.00 (49.74) Full [+] 1.94 (7.73) [+]
RBNGS0120087 Soojin Y04-21 caudate nucleus 0.00 (49.4)
0.00 (49.40) Full [+] 1.81 (3.61) [+]
RBNGS0120089 Soojin Y04-21 hippocampus 0.00 (49.46)
0.00 (49.46) Full [+] 1.84 (4.64) [+]
RBNGS0120092 Wang individual kidney 24.19 (91.05)
1393.19 (99.97) Full [+] 6.2 (47.94) [+]
RBNGS0120093 Wang individual liver 18.73 (93.93)
338.16 (99.64) Full [+] 5.98 (43.3) [+]
RBNGS0120095 Wang individual testis 7.29 (75.02)
118.24 (98.89) Full [+] 6.42 (53.09) [+]
RBNGS0120094 Wang individual muscle 5.05 (82.04)
5119.89 (99.98) Full [+] 6.58 (55.67) [+]
RBNGS0120091 Wang individual heart 4.64 (81.54)
912.82 (99.92) Full [+] 4.78 (14.95) [+]
RBNGS0120090 Wang individual brain 2.99 (64.6)
917.80 (99.99) Full [+] 6.28 (48.97) [+]
RBNGS0120096 Yi individual cerebellum 1.64 (58.22)
520.64 (99.96) Full [+] 5.7 (25.26) [+]
RPKM Comparison
Human 
Macaque 
Mouse 
1.99
 
1.33
 
1.36
 
2.70
 
1.80
 
1.32
 
17.42
 
7.68
 
19.25
 
23.96
 
17.21
 
13.60
 
32.33
 
9.93
 
5.71
 
brain cerebellum heart kidney testis
Percentile Rank Comparison
Human 
Macaque 
Mouse 
55.77
 
59.49
 
49.47
 
61.62
 
61.50
 
49.22
 
91.16
 
87.21
 
90.47
 
90.29
 
90.25
 
83.40
 
91.21
 
79.84
 
69.69
 
brain cerebellum heart kidney testis
Relative RPKM Comparison
Human 
Macaque 
Mouse 
0.003
 
0.003
 
N.A
 
0.003
 
0.003
 
N.A
 
0.020
 
0.010
 
N.A
 
0.038
 
0.027
 
N.A
 
0.060
 
0.062
 
N.A
 
brain cerebellum heart kidney testis